[1] Chen F,Archambault V,Kar A,et al. Multiple protein phosphatases are required for mitosis in Drosophila[J]. Curr Biol,2007,17(4):293-303. [2] Chen HF,Mai JR,Wan JX,et al. Role of a novel functional variant in the PPP2R1A promoter on the regulation of PP2A-A alpha and the risk of hepatocellular carcinoma[J]. PLoS One,2013,8(3):59574. [3] Janssens V,Goris J,Van Hoof C. PP2A:the expected tumor suppressor[J]. Curr Opin Genet Dev,2005,15(1):34-41. [4] Alberts AS,Thorburn AM,Shenolikar S,et al. Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases[J]. Proc Natl Acad Sci USA,1993,90(2):388-392. [5] Moule MG,Collins CH,McCormick F,et al. Role for PP2A in ARF signaling to p53[J]. Proc Natl Acad Sci USA,2004,101(39):14063-14066. [6] Yeh E,Cunningham M,Arnold H,et al. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells[J]. Nat Cell Biol,2004,6(4):308-318. [7] Vuocolo S,Purev E,Zhang D,et al. Protein phosphatase 2A associates with Rb2/p130 and mediates retinoic acid-induced growth suppression of ovarian carcinoma cells[J]. J Biol Chem,2003,278(43):41881-41889. [8] Xu Y,Xing Y,Chen Y,et al. Structure of the protein phosphatase 2A holoenzyme[J]. Cell,2006,127(6):1239-1251. [9] Hunt T. On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis[J]. Adv Biol Regul,2013, 53(2):173-178. [10] Zolnierowicz S,Csortos C,Bondor J,et al. Diversity in the regulatory B-subunits of protein phosphatase 2A:identification of a novel isoform highly expressed in brain[J]. Biochemistry,1994,33(39):11858-11867. [11] Wang SS,Esplin ED,Li JL,et al. Alterations of the PPP2R1B gene in human lung and colon cancer[J]. Science,1998,282(5387):284-287. [12] Chen W,Arroyo JD,Timmons JC,et al. Cancer-associated PP2A-A alpha subunits induce functional haploinsufficiency and tumorigenicity[J]. Cancer Res,2005,65(18):8183-8192. [13] 林丽娜,林育纯,陈慧峰,等. PP2A-B56γ高表达抑制镉诱导的人肝L02细胞DNA损伤[J]. 癌变·畸变·突变,2012,24(3):189-194. [14] Kalev P,Sablina AA. Protein phosphatase 2A as a potential target for anticancer therapy[J]. Anticancer Agents Med Chem,2011,11(1):38-46. [15] Healy AM,Zolnierowicz S,Stapleton AE,et al. Cdc55,a saccharomyces-cerevisiae gene involved in cellular morphogenesis:identification,characterization,and homology to the B-subunit of mammalian type-2a protein phosphatase[J]. Mol Cell Biol,1991, 11(11):5767-5780. [16] Turowski P,Myles T,Hemmings BA,et al. Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55[J]. Mol Biol Cell,1999,10(6):1997-2015. [17] Seeling JM,Miller JR,Gil R,et al. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A[J]. Science, 1999,283(5410):2089-2091. [18] Seshacharyulu P,Pandey P,Datta K,et al. Phosphatase:PP2A structural importance,regulation and its aberrant expression in cancer[J]. Cancer Lett,2013,335(1):9-18. [19] Krasinska L,Domingo-Sananes MR,Kapuy O,et al. Protein phosphatase 2A controls the order and dynamics of cell-cycle transitions[J]. Mol Cell,2011,44(3):437-450. [20] Yu JT,Fleming SL,Williams B,et al. Greatwall kinase:a nuclear protein required for proper chromosome condensation and mitotic progression in Drosophila[J]. J Cell Biol,2004,164(4):487-492. [21] Vigneron S,Brioudes E,Burgess A,et al. Greatwall maintains mitosis through regulation of PP2A[J]. EMBO J,2009,28(18):2786-2793. [22] Castilho PV,Williams BC,Mochida S,et al. The M phase kinase greatwall (Gwl) promotes inactivation of PP2A/B55 delta,a phosphatase directed against CDK phosphosites[J]. Mol Biol Cell,2009,20(22):4777-4789. [23] Mochida S,Maslen SL,Skehel M,et al. Greatwall phosphorylates an inhibitor of protein phosphatase 2A:That is essential for mitosis[J]. Science,2010,330(6011):1670-1673. [24] Jeong AL,Yang Y. PP2A function toward mitotic kinases and substrates during the cell cycle[J]. Bmb Reports,2013,46(6):289-294. [25] Schmitz MH,Held M,Janssens V,et al. Live-cell imaging RNAi screen identifies PP2A-B55 alpha and importin-beta 1 as key mitotic exit regulators in human cells[J]. Nat Cell Biol,2010,12(9):886-893. [26] Mochida S,Ikeo S,Gannon J,et al. Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts[J]. EMBO J,2009,28(18):2777-2785. [27] Chang KE,Wei BR,Madigan JP,et al. The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity[J]. Mol Cancer Ther,2015,14(1):90-100. [28] Bai XL,Zhang Q,Ye LY,et al. Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas[J]. Mol Cancer Ther,2014,13(8):2062-2072. [29] Lv P,Wang Y,Ma J,et al. Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair[J]. Oncotarget,2014,5(17):7512-7524. [30] Gong FR,Wu MY,Shen M,et al. PP2A inhibitors arrest G2/M transition through JNK/Sp1-dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21[J]. Oncotarget,2015, 6(21):18469-18483. [31] Chien W,Sun QY,Lee KL,et al. Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer[J]. Mol Oncol,2015,9(4):889-905. [32] Rincon R,Cristobal I,Zazo S,et al. PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects[J]. Oncotarget,2015, 6(6):4299-4314. [33] Ito A,Kataoka TR,Watanabe M,et al. A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation[J]. EMBO J,2000,19(4):562-571. [34] Ito A,Koma Y,Watabe K,et al. A truncated isoform of the protein phosphatase 2A b56 gamma regulatory subunit may promote genetic instability and cause tumor progression[J]. Am J Pathol,2003,162(1):81-91. [35] Wang L,Guo Q,Fisher LA,et al. Regulation of polo-like kinase 1 by DNA damage and PP2A/B55 alpha[J]. Cell Cycle,2015,14(1):157-166. |