Abstract: OBJECTIVE: To investigate whether the polymorphisms of Arg194Trp on X-ray repair cross-complementing group 1(XRCC1) would influence susceptibility to colorectal cancer among Chinese. METHODS: We collected publications which discussed association between polymorphisms of XRCC1 Arg194Trp and susceptibility to colorectal cancer in Chinese people by searching the databases (wanfangdata, CBM, CNKI, VIP, PubMed, EBASE). The pooled ORs with their 95%CI were calculated by using Review Manager 5.1 software. We also conducted the heterogeneity and sensitivity, publication bias and subgroup analyses. RESULTS: After filtering, 10 studies were included on the selection criteria. The result of this Meta-analysis demonstrates:homozygous model, OR=1.40, 95%CI (1.13-1.73), P=0.002;dominant model, OR=1.22, 95%CI(1.01-1.47), P=0.04;recessive model, OR=1.30, 95%CI (1.06-1.60), P=0.01;heterozygous model, OR=1.19, 95%CI(1.00-1.42), P=0.05. In the subgroup analysis, the value of OR between smokers in case group and smokers in control group is 1.04, 95%CI(0.84-1.29), P=0.72;the value of OR between drinkers in case group and drinkers in control group is 1.08, 95%CI(0.81-1.44), P=0.60. CONCLUSION: The polymorphisms of Arg194Trp on XRCC1 contributed to susceptibility of colorectal cancer. Those who carried the 194Trp genotype had increased risk of colorectal cancer in the dominant, homozygous and recessive models. Smoking and drinking had no significant correlation with the incidence of colorectal cancer.

Key words: Chinese, X-ray repair cross-complementing group 1, Arg194Trp, polymorphisms, colorectal cancer, susceptibility, Meta-analysis