GJB2基因多态性与汉族人群职业噪声性听力损失相关性的研究

doi:10.3969/j.issn.1004-616x.2016.02.008

Abstract

Abstract: OBJECTIVE: To investigate whether any of the three polymorphisms (rs2274083, rs2274084, rs72474224) of GJB2 are associated with susceptibility to occupational noise-induced hearing loss in Chinese Han population. METHODS: A 1:1 case-control study was conducted using 177 cases with average hearing threshold of no less than 40 dB in high frequency and 177 controls with average hearing threshold of less than 25 dB in high frequency. Controls were matched with cases according to gender, age, duration of noise exposure and working positions. The genotypes were sequenced after polymerase chain reaction. RESULTS: There was statistically significant differences in the distribution of genotypes and alleles frequencies of rs2274084 between cases and controls. The rs2274084 C and T allele frequencies in cases and controls were 73.73%, 26.27% and 63.84%, 36.16%. The CC genotypes, TC genotypes, TT genotypes in cases and controls were 55.37%, 36.72%, 7.91% and 40.11%, 47.46%, 12.43% respectively. There was no statistically significant difference in the distribution of genotypes of rs2274083 and rs7274224 between cases and controls. CONCLUSION: The data suggest that GJB2 rs2274084 might be the susceptibility gene locus of noise-induced hearing loss in Chinese workers. In addition, workers with the C genotype in rs2274084 might be susceptible to noise-induced hearing loss.

Key words: noise-induced deafness, polymorphism, susceptibility gene, gap junction protein beta 2

CLC Number:

R994.6

YU Decai, MIAO Long, YANG Wenwen, ZHANG Juan, YIN Lihong, PU Yuepu. Association between GJB2 genetic polymorphisms and occupational hearing loss in Chinese Han population[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(2): 121-124,130.

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Association between GJB2 genetic polymorphisms and occupational hearing loss in Chinese Han population

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