E-钙黏蛋白异常表达与鼻咽癌临床病理关系的Meta分析

doi:10.3969/j.issn.1004-616x.2016.02.003

Abstract

Abstract: OBJECTIVE: To understand the relationship between aberrant expression of E-cadherin in nasopharyngeal carcinoma (NPC) and clinicopathological features of NPC patients for clinical applications. METHODS: International publications about E-cadherin and NPC were selected from the Cochrane Library, Pubmed, EMbase database, and Chinese publications were from CBM, CNKI. All analyses were performed by software STATA 11.0. Abnormal expression, degree of differentiation, T stage, lymph node metastasis, and clinical stage were analyzed using pooled odds ratio (OR) with 95% confidence interval (CI). RESULTS: A total of 16 studies including 1040 patients were enrolled in the Meta-analysis. It was shown that expression of E-cadherin was significantly increased in NPC compared to that in normal tissues (OR=0.096, 95% CI:0.036-0.252, P=0.000). In addition, the aberrant expression of E-cadherin was significantly associated with the degree of differentiation, lymph node metastasis and clinical stages (OR=0.232, 95% CI:0.061-0.884, P=0.032;OR=0.324, 95% CI:0.198-0.53, P=0.000;OR=0.441, 95% CI:0.232- 0.835, P=0.012). CONCLUSION: NPC often showed aberrant expression of E-cadherin. In addition, patients with the aberrant expression were prone to having tumors at lower differentiation, with lymph node metastasis and at late clinical stage. E-cadherin may be an indicator for differentiation, lymph node metastasis and clinical stage.

Key words: E-cadherin, aberrant expression, nasopharyngeal carcinoma, Meta- analysis

CLC Number:

R73-31

JING Shaowu, XU Qing, WANG Jun, YANG Congrong, LI Guangqing, ZHAO Zhen, ZHAO Zhijun, JING Shanghua. Relationship between aberrant expression of E-cadherin and clinicopathological characteristics of nasopharyngeal carcinoma: a Meta-analysis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(2): 97-102,106.

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Relationship between aberrant expression of E-cadherin and clinicopathological characteristics of nasopharyngeal carcinoma: a Meta-analysis

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