三七的急性毒性及致突变性试验研究

doi:10.3969/j.issn.1004-616x.2016.01.014

Abstract

Abstract: OBJECTIVE: To access the safety of Panaxnotoginseng as a health food through assessing its acute toxicity and mutagenicity. METHODS: Oral acute toxicity test,mouse bone marrow micronucleus test,mouse sperm malformation test,Ames test were performed according to the national standard procedures for toxicological assessment of foods. RESULTS: The MTD of Panaxnotoginseng in mouse was more than 15 g/kg,the polychromatic eryrocyte micronucleus rates,sperm abnormality rates at all doses (10.00,5.00,2.50 g/kg) were not significantly different from the solvent control. In the presence or absence of S9 or not,the number of revertant colonies in six dose groups (2,8,40,200,1 000,5 000 μg/plate) did not exceed 2- fold of the spontaneous revertant colony number,nor was there a dose-response relationship,the results of Ames test was negative. CONCLUSION: Panaxnotoginseng did not show acute toxicity and mutagenicity under our study conditions.

Key words: Panaxnotoginseng, acute toxicity, mutagenicity, micronucleus test, mouse sperm malformation test, Ames test

CLC Number:

Q394.6

TANG Jiao, ZHAO Min, YANG Ying, LI Qing, HUANG Junming, YANG Xingfen. Study on acute toxicity and mutagenicity of Panaxnotoginseng[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(1): 66-68,72.

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Study on acute toxicity and mutagenicity of Panaxnotoginseng

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