广东潮汕贲门癌组织中GST-π和P-gp的表达及其临床病理意义

doi:10.3969/j.issn.1004-616x.2016.01.008

Abstract

Abstract: OBJECTIVE: To study the expression of glutathione-s-transferase-π (GST-π) and P-glycoprotein (P-gp) in gastric cardia the cancer in the Chaoshan high risk area and their relationships with clinical pathological characteristics of gastric cardia cancer. METHODS: Immunohistochemical staining was used to detect the expression of GST-π and P-gp in 87 cases of gastric cardia cancer. The correlations between GST-π,P-gp expression and the clinical characteristics of gastric cardia cancer were analyzed. ROC curves of age and maximum tumor diameter were plotted. RESULTS: The positive expression rate of GST-π and P-gp in gastric cardia cancer were 85.05% and 93.1%,respectively. The cutoff points of grouping for age and maximum tumor diameter depended upon the results of ROC curves. The expression of GST-π was related to lymph-vascular space invasion. The expression rate of GST-π of patients with lymph-vascular space invasion was signi?cantly higher than that without the invasion(P<0.05). Expression of P-gp was related to the age of patients and the histological type of gastric cardia cancer. Cancer tissues from elder patients and mucinous adenocarcinomas showed significantly higher rate of expression of P-gp (P<0.05). GST-π expression was positively correlated to P-gp expression (P<0.01). CONCLUSION: GST-π and P-gp expression were high in gastric cardia cancer in the Chaoshan area. Their expression was positively correlated. High GST-π expression was associated with lymph-vascular space invasion. High P-gp expression was associated with elder patients and mucinous adenocarcinoma tissues.

Key words: gastric cardia cancer, glutathione-s-transferase-π, P-glycoprotein, immunohistochemistry

CLC Number:

R730.2

CHEN Guangcan, HONG Liangli, HUANG Jiexiong, XIE Aosi, GUO Dan, LIU Shuhui. Expression of GST-π and P-gp in gastric cardia cancer and their clinical significance in the Chaoshan high risk area[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(1): 36-40.

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Expression of GST-π and P-gp in gastric cardia cancer and their clinical significance in the Chaoshan high risk area

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