miR-143、MMP-2和TIMP-1在哈萨克族食管癌组织中的表达及其临床病理意义

doi:10.3969/j.issn.1004-616x.2016.01.007

Abstract

Abstract: OBJECTIVE: To study expressions of miR-143,matrix metalloproteinase-2(MMP-2) and tissue inhibitor of metalloproteinase-1(TIMP-1) in esophageal cancer tissue and normal tissue among Kazaks and to investigate the relationship between their expressions and clinical pathological features. METHODS: Using real time-PCR to detect the expression of miR-143,MMP-2 and TIMP-1 in 30 esophageal cancer specimens. RESULTS: The expression levels of miR-143 in cancer tissue were lower than those of normal tissues(P=0.000).The lower expression of miR-143 was significantly related to the cellular differentiation lymph node metastasis and clinical stage (P=0.042,0.039 0.007).The expression levels of MMP-2,TIMP-1 in cancer tissue were higher than those of normal tissues(P=0.026 0.021).Enhanced expression of MMP-2 was significantly related to lymph node metastasis(r=0.367,P=0.037).The expression of miR-143 in the Kazak's esophageal cancer was negatively related to the expressions of MMP-2 and TIMP-1 (r=-0.442,-0.410; P=0.001,0.003).The expression of MMP-2 positively related to that of TIMP-1(r=0.794,P= 0.000). CONCLUSION: The under-expression of miR-143 and over-expressions of MMP-2 and TIMP-1 may have important roles in carcinogenesis of esophageal cancer in Kazaks.

Key words: esophageal cancer, miR-143, matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1

CLC Number:

R734.2

LI Xiumei, GUO Qiong, WANG Dong, CHEN Yan, LI Hui, CHEN Hongming, LI Huiwu. Expression and significance of miR-143, MMP-2 and TIMP-1 in esophageal cancer in Kazaks[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(1): 32-35,40.

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Expression and significance of miR-143, MMP-2 and TIMP-1 in esophageal cancer in Kazaks

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