桑芪胶囊的一般毒性和致突变性研究

doi:10.3969/j.issn.1004-616x.2015.06.014

Abstract

Abstract: OBJECTIVE: To evaluate the general toxicity and mutagenic effects of Mulberry-Astragalus capsule. METHODS: Acute toxicity test and 30-day feeding study in rats were carried out to observe the general toxicity of Mulberry-Astragalus capsule. Ames test,bone marrow micronucleus test and sperm malformation test in mice were carried out to observe the mutagenic effects of Mulberry-Astragalus capsule. All the tests were conducted according to the standard procedures. RESULTS: MTD of Mulberry-Astragalus capsule on mice was >20 g/kg in this experiment. In the three mutagenicity tests,no mutagenic effect was seen in any Mulberry-Astragalus capsule treated groups. And in 30-day feeding study,no adverse effects were found when the highest does was 8.33 g/kg. CONCLUSION: The results from this study showed Mulberry-Astragalus capsule had no general toxicity and mutagenic effects and further functional studies,such as hypoglycemic effect could be carried out.

Key words: Mulberry-Astragalus capsule, acute toxicology, mutagenicity, 30-day feeding study

CLC Number:

R114

YAN Jiuming, YUE Qianlan, JIA Zhenchao, LI Yan, ZHANG Lishi. General toxicity and mutagenic effects of Mulberry-Astragalus capsule[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(6): 472-476.

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General toxicity and mutagenic effects of Mulberry-Astragalus capsule

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