KCNQ4和GJB2基因多态性与职业噪声性听力损失的相关性研究

doi:10.3969/j.issn.1004-616x.2015.04.006

Abstract

Abstract: OBJECTIVE: To explore the correlation between KCNQ4,GJB2 genetic polymorphisms and noise-induced hearing loss. METHODS: 1:1 matched case-control design was used in this study. The genetic polymorphisms of KCNQ4 rs34287852 and GJB2 rs3751385 were detected by polymerase chain reaction and direct sequencing in 103 pairs of hearing loss workers and normal workers with same noise exposure. The relationship between target SNPs and noise induced hearing loss (NIHL) were analyzed. RESULTS: There is no statistical difference of the frequency of T,G alleles and genotypes in KCNQ4 rs34287852 between cases and controls. The frequency of C allele and CC mutation genotype in GJB2 rs3751385 was significantly higher in case group than that in control group. Workers carried CC homozygous mutations were at the 2.78 fold risk of developing hearing loss than individuals with TT wild homozygous type when they exposed to the occupational noise. CONCLUSION: There was the correlation between GJB2 rs3751385 mutation and NIHL and the CC genotype might be susceptible genotype of NIHL.

Key words: KCNQ4, GJB2, noise-induced hearing loss, polymorphisms

CLC Number:

R135.8

TAN Kehong, YU Decai, ZHANG Juan, YIN Lihong, PU Yuepu. The correlation of KCNQ4 and GJB2 genetic polymorphisms and occupational noise-induced hearing loss[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(4): 284-287.

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The correlation of KCNQ4 and GJB2 genetic polymorphisms and occupational noise-induced hearing loss

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