Sema4C在喉鳞状细胞癌组织中的表达及意义

doi:10.3969/j.issn.1004-616x.2015.03.015

Abstract

Abstract:

OBJECTIVE: To investigate the expression of semaphorin 4C(Sema4C) in laryngeal squamous carcinoma and its role in tumor proliferation and lymphatic metastasis. METHODS:We investigated the expression of Sema4C and MCM2 in 82 cases of laryngeal squamous carcinoma and normal laryngeal tissues by immunohistochemical technique.Furthermore, we used D2-40 to label the lymphatic microvessel and measure the lymphatic microvessel density(LMVD) to analyze their roles in laryngeal squamous carcinoma. RESULTS:The expressions of Sema4C and MCM2 in laryngeal squamous carcinoma were significantly higher than that in the normal laryngeal tissues (P<0.01), but the difference of LVMD was not significant (P0.077). The aberrant expression rates of Sema4C, MCM2 and LVMD in laryngeal squamous carcinoma were closely related to lymph node metastasis but did not correlate with age and T stage. LMVD in laryngeal squamous carcinoma should positive correlation with the expressions of Sema4C (P<0.05) and MCM2 (P<0.01)． Moreover, there was positive correlation between Sema4C and MCM2 (P<0.05)．CONCLUSION:Sema4C may play a role in the development of laryngeal squamous carcinoma. It may be possible to follow the progression of the disease and provide prognosis by detecting the expression of Sema4c.

Key words: laryngeal squamous carcinoma, Sema4C, minichromosome maintenance 2, immunohistochemistry, lymphatic microvessel density

CLC Number:

R730.2

QIN Jiesheng, HONG Liangli, LIN Xuni, WANG Huige, QIU Qiancheng. Expression and significance of Sema4C in laryngeal squamous carcinoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(3): 230-233.

References

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Expression and significance of Sema4C in laryngeal squamous carcinoma

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