食用竹炭粉的急性毒性与致突变性研究

doi:10.3969/j.issn.1004-616x.2015.02.014

Abstract

Abstract:

OBJECTIVE:To evaluate the acute toxicity and mutagenicity of bamboo charcoal powder (BCP). METHODS:Oral acute toxicity test, Ames test, rat bone marrow micronucleus test and in vivo comet assay were conducted according to the OECD standards. Dose designed for oral acute toxicity test was 20 mL/kg. Doses were designed at 0.008, 0.04, 0.2, 1, 5 mg/plate of Ames test, at 2.81, 5.62, 11.24 g/kg of micronucleus test and at 2.81, 5.62, 11.24 g/kg of in vivo comet assay. RESULTS:The mean volume diameter of BCP was 16.596 μm. The LD₅₀ of BCP in rats was > 11.24 g/kg in this experimental condition. In the three mutagenicity tests, no mutagenic effect was observed in any BCP-treated group compared to the control group. CONCLUSION:BCP is a micro-sized mixture, and was non-toxic according to acute toxicity classification, and showed no mutagenic effect in this experimental design.

Key words: bamboo charcoal powder, acute toxicity, mutagenicity, rats, mice

CLC Number:

R972

ZHONG Yuting, JIA Zhenchao, YAN Jiuming, LUO Sha, LU Yedan, ZHANG Lishi. Study of acute toxicity and mutagenicity of bamboo charcoal powder[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(2): 142-145.

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Study of acute toxicity and mutagenicity of bamboo charcoal powder

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