Abstract:

OBJECTIVE:To investigate the expression of silent information regulator 1(SIRT1) in bladder urothelial cell carcinoma (BUC), and analyze its clinical significance. METHODS:The expression of SIRT1 protein was assessed by immunohistochemistry in bladder sections of 19 normal bladders and 72 patients with BUC. We analyzed the relationship of SIRT1 and the pathological grade and clinical stage of BUC. RUSULTS:SIRT1 was observed in normal bladder samples and BUC．Normal bladder showed negative or weakly positive expression of SIRT1(31.58%), however BUC samples showed moderately or strongly positive expression(77.78%). Furthermore, the expression level of SIRT1 increased with tumor pathological grade and clinical stage. SIRT1 positive expression rates showed significant difference between various pathology grades (P<0.05). CONCLUSION:SIRT1 was high expressed in BUC, and was related to its pathological grade and clinical stage, making it a useful tumor marker and a possible indicator for estimating the invasiveness and recurrence of BUC．Blocking SIRT1 expression and its functions may become targeted therapy of bladder cancer treatment．

Key words: bladder urothelial cell carcinoma, silent information regulator 1, immunohistochemistry, tumor marker