UHRF1蛋白在结直肠癌中的表达情况及其预后判断价值

doi:10.3969/j.issn.1004-616x.2015.01.007

Abstract

Abstract:

OBJECTIVE: This study aimed to evaluate the expression and prognostic significance of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) protein in colorectal cancer (CRC). METHODS：The expression of UHRF1 in 201 CRC cases and adjacent normal tissues were detected by tissue microarrays and immunohistochemistry (TMA-IHC)，then the relationship between UHRF1 protein expression and clinio-pathological parameters as well as its prognostic value were examined by statistical analysis. RESULTS：Positive expression of UHRF1 was observed in 54.2% (109/201) of CRC tissues，and the frequency in CRC was significantly higher than that in adjacent nomal tissues (P<0.01). Kaplan-Meier survival curves showed that CRC patients with negative expression of UHRF1 had shorter overall survival time (P=0.023). Cox regression analysis indicated that UHRF1 protein expression was an independent prognostic factor (P=0.008). CONCLUSION：UHRF1 might be a biomarker for prognostic evaluation of CRC patients.

Key words: UHRF1, colorectal cancer, molecular marker, prognostic evaluation

WU Lifei1, HAO Jiajie，ZHANG Tongtong，LIANG Jianwei，WANG Zheng，ZHANG Yu，XU Xin，CAI Yan，WANG Mingrong，LI Min. Expression and prognostic value of UHRF1 in colorectal cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2015.01.007.

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Expression and prognostic value of UHRF1 in colorectal cancer

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