鼻咽癌中EMP1蛋白的表达及其临床意义

doi:10.3969/j.issn.1004-616x.2014.04.014

Abstract

Abstract:

OBJECTIVE: This study aimed to analyze the expression，clinical significance of epithelial membrane protein-1(EMP1) in nasopharyngeal carcinoma. METHODS：Immunohistochemistry and western blot were used to analyze EMP1 protein expression in 75 cases of nasopharyngeal carcinoma and normal tissues to study the relationship between EMP1 expression and clinical factors. RESULTS：Immunohistochemistry：The level of EMP1 protein expression was found to be significantly lower in nasopharyngeal carcinoma tissue than normal tissues (P<0.05). Western blot：The relative amount of EMP1 protein in nasopharyngeal carcinoma tissue was found to be significantly lower than in normal tissues (P<0.05). The level of EMP1 protein expression correlated with lymph node metastasis，clinical stage and histological grades (P<0.05). CONCLUSION：Decreased expression of EMP1 may play important roles in the pathogenesis and progression of nasopharyngeal carcinoma.

Key words: epithelial membrane protein-1, nasopharyngeal cancer, immunohistochemistry, Western blot

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Expressions and significance of EMP1 in nasopharyngeal carcinoma

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