MMP-2和E-cadherin蛋白在食管黏膜病变中的表达

doi:10.3969/j.issn.1004-616x.2014.04.011

Abstract

Abstract:

OBJECTIVE: To explore the relationship between the protein expressions of MMP-2 and E-cadherin and the development and metastasis of esophageal carcinoma. METHODS：The expressions of E-cadherin protein and MMP-2 protein were examined by immunohistochemistry (IHC) in 45 cases of esophageal carcinoma，21 cases of atypical hyperplasia and 24 cases of normal esophageal mucosa tissues. RESULTS：The positve rates of MMP-2 protein were 40.00% (18/45) in esophageal carcinoma，38.1% (8/21) in esophageal atypical hyperplasia and 4.17% (1/24) in normal tissues. There were significant differences among three groups (P<0.05). Additionally，the expression of MMP-2 protein had a correlation with lymph node metastasis (P<0.05). The positve rate of MMP-2 protein in esophageal cancer tissues with lymph node metastasis was 55.56% (15/27) ， significantly higher than that in esophageal cancer tissues without lymph node metastasis (16.67%，3/18). The positve rate of MMP-2 protein in esophageal cancer tissues with fibrous membrane infiltration was higher than that in esophageal cancer tissues without fibrous membrane infiltration(48.57%，17/35；10.00%，1/10). The positive rate of E-cadherin protein in normal tissues (100%) was much higher than that in esophageal carcinoma (28.89%) and esophageal atypical hyperplasia (71.43%). According to these results，the expression of E-cadherin protein had a negative correlation with the expression of MMP-2 protein (χ2=4.615，r=-0.793，P<0.05). CONCLUSION：There were significant relationships between the high expression of MMP-2 protein and low expression of E-cadherin protein with the development and metastasis of esophageal carcinoma. Furthermore，the expression of E-cadherin protein had a negative correlation with the expression of MMP-2 protein in the invasion and metastasis of esophageal carcinoma.

Key words: esophageal mucosal lesion, MMP-2, E-cadherin, immunohistochemistry

References

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Expressions of MMP-2 and E-cadherin in esophageal mucosal lesion Expressions of MMP-2 and E-cadherin in esophageal mucosal lesion

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