红丝线草对大鼠的致畸性研究

doi:10.3969/j.issn.1004-616x.2014.03.015

Abstract

Abstract:

OBJECTIVE: To determine the teratogenic effects of peristrophe roxburghiana (Schult.) brem in rats. METHODS：Pregnant rats were divided into 5 groups，each with 12 rats. Three groups were treated orally with exract from peristrophe roxburghiana for 10 days from 6th to 15th day of pregnancy with doses of 10.0，5.0，2.5 g/kg. The other two groups were fed orally with deionized water as negative control and aspirin with 0.3 g/kg as positive control. At 20th day，the rats were sacrificed to allow physical examination of the fetuses. RESULTS：In all treated groups the body weight of parental rats， litter weight， live rate， fetus body weight and fetus length were not significantly different from negative control group (P>0.05)，and no abnormality of organ or external was found in the fetuses. CONCLUSION：In these experimental conditions，peristrophe roxburghiana had no appearance maternal toxicity，embryo toxicity nor teratogenicity in rats.

Key words: peristrophe roxburghiana, rat, embryo toxicity, teratogenicity

HUANG Chao-pei，FU Wei-zhong，WANG Yan-wu，HE Li，ZHANG Jie-hong，PENG Liang. Teratogenicity of peristrophe roxburghiana in rats[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2014.03.015.

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Teratogenicity of peristrophe roxburghiana in rats

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