联合检测Fascin与EGFR对食管鳞癌患者预后判断的价值

doi:10.3969/j.issn.1004-616x.2014.03.008

Abstract

Abstract:

OBJECTIVE: Esophageal squamous cell carcinoma (ESCC) is still the leading cancer-caused mortality in China，and 5-year survival remains poor. The aim of this study is to survey the ability that coexpression of Fascin and EGFR predicts ESCC prognosis. METHODS：We collected 189 formalin-fixed paraffin-embedded esophageal curative resection specimens，and then constructed tissue microarray. Immunohistochemistry (IHC) was used for detecting the co-expression of Fascin and EGFR. Statistical analyses were performed using SPSS 13.0 for windows. RESULTS：Our IHC results showed that positive rates of high-expression of Fascin and EGFR were 35.4% and 56.1%，respectively. Positive rate of co-expression of Fascin and EGFR was 29.5%. The Kendall’s tau-b correlation analysis indicated that EGFR expression was associated with regional lymph node metastasis. Positive rate of EGFR without regional lymph node metastasis was 49.6%，while it was 68.7% with regional lymph node metastasis，P=0.014. Kaplan-Meier survival analysis showed that high-expression of Fascin and EGFR were associated with poor survival，while co-expression of Fascin and EGFR presented poorer survival. Pearson’s rank correlation analysis illustrated that there was a significant correlation between Fascin and EGFR. The multivariate Cox stepwise regression analysis demonstrated that Fascin/EGFR coexpression was a passive independent poor prognostic factor for overall survival. The RR for patients with high-coexpression of Fascin/EGFR was 1.987 ，just a little higher than RR for high-expression of Fascin. The ROC curve analysis indicated that the specificity of the combination of Fascin and EGFR was more robust than that of a single biomarker. CONCLUSION：This study has successfully showed that co-expression of Fascin and EGFR could confer a poor prognosis.

Key words: Fascin, EGFR, ESCC, prognosis

YAO Xiao-dong，CAO Hui-hui，WU Jian-yi，XU Xiu-e，ZHENG Chun-peng，SHEN Jin-hui，WANG Shao-hong，XU Li-yan，WU Zhi-yong. Co-expression of Fascin and EGFR predicts esophageal squamous cell carcinoma prognosis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2014.03.008.

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Co-expression of Fascin and EGFR predicts esophageal squamous cell carcinoma prognosis

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