菁染料五甲川菁的遗传毒性研究

doi:10.3969/j.issn.1004-616x.2014.02.012

Abstract

Abstract:

OBJECTIVE: To study the genetic toxicity of 5-polymethine cyanine(Cy5)，and to provide scientific evidence for its safe use. METHODS：Mice were randomly divided into five groups，including negative group (saline)，positive group (cyclophosphamide，CP) and test groups with different doses of Cy5 (2，20，200 mg/kg). Micronucleus test in mice bone marrow polychromatic erythrocytes，mice sperm shape abnormality test，mice marrow chromosome aberration test and Ames test were used to investigate the genetic toxicity of Cy5. RESULTS：Bone marrow micronucleus test，sperm shape abnormality test and marrow chromosome aberration test，in each Cy5 test group compared with the negative control group and the differences between the test groups were statistically insignificant(P＞0.05)，while each positive group compared with the negative control group was statistically significant (P＜0.05). Ames test showed negative reaction. CONCLUSION：Under the conditions of this experiment，Cy5 has genetic toxic effect was not found in mice.

Key words: cyanine dyes, 5-polymethine cyanine, genetic toxicity, mutagenesis

WU Yu-long，WU Xiang-hua，ZHANG Dun-lin. The genetic toxicity of 5- polymethine cyanine[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2014.02.012.

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The genetic toxicity of 5- polymethine cyanine

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