The phenotypic changes of thymic regulatory T cells induced by ATP
LIU Lan-tao，LIU Jian-xiang，SU Xu
China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China
LIU Lan-tao，LIU Jian-xiang，SU Xu. The phenotypic changes of thymic regulatory T cells induced by ATP[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2014.02.004.
[1] Tang Q，Blueston JA. The FOXP3+ regulatory T cell：a jack of all trades，master of regulation[J]. Nat Immunol，2008，9(3)： 239-244.[2] Dwyer KM，Deaglio S，Gao W，et al. CD39 and control of cellular immune responses[J]. Purinergic Signal，2007， 3(1/2)：171-180[3] Zheng SG，Wang J，Horwitz DA. Cutting edge： FOXP3+-CD4+CD25+ regulatory T cells induced by IL-2 and TGF-β are resistant to Th17 conversion by IL-6[J]. J Immunol，2008， 180(11)：7112–7116.[4] Huang CT，Workman CJ，Flies D，et al. Role of LAG-3 in regulatory T Cells[J]. Immunity，2004，21(4)：503–513.[5] 刘澜涛，刘建香，苏 旭. γ射线照射诱导胸腺中调节性T 细胞表型改变的研究[J]. 癌变·畸变·突变，2013， 25(3)： 173-176.[6] Trabanelli S，Ocadlikova D，Gulinelli S，et al. Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation[J]. J Immunol， 2012，189(3)：1303-1310.[7] Marcus AJ，Broekman MJ，Droscopoulos JH，et al. Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1：implications for ischemic vascular disease[J]. J Pharmacol Exp Ther，2003，305(1)：9-16[8] Mariathasan S，Monack DM. Inflammasome adaptors and sensors：intracellular regulators of infection and inflammation [J]. Nat Rev Immunol，2007，7(1)：31-40.[9] Borsellino G，Kleinewietfold M，Dimitri D，et al. Expression of ectonucleotidase CD39 by FOXP3+ Treg cells：hydrolysis of extracellular ATP and immune suppression[J]. Blood，2007， 110(4)：1225-1232.[10] Ralevic V，Burnstock G. Involvement of purinergic signaling in cardiovascular disease[J]. Drug News Perspect，2003， 16(3)： 133-140.[11] Fredholm BB，AP IJ，Jacobson KA，et al. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors[J]. Pharmacol Rev，2001，53(4)：527-552.
