Carcinogenesis, Teratogenesis & Mutagenesis

Previous Articles     Next Articles

Study on mutagenicity of 2,4-dichlorophenoxyacetic acid

LIU Yong-xia*,GE Yang,ZHANG Zhen-ling,XIE Lin   

  1. (Shandong Academy of Occupational Health  and Occupational Medicine,Jinan 250002,Shandong,China)
  • Received:2013-08-02 Revised:2013-12-04 Online:2014-01-30 Published:2014-01-30
  • Contact: LIU Yong-xia,Tel:0531-82595632;E-mail:liuyongxia63@163.com

Abstract:

OBJECTIVE:  To  explore  the  potential  mutagenicity  of  24-dichlorophenoxyacetic  acid.  METHODSAmes  testmouse  bone  marrow  micronucleus  test  and  mouse  primary  spermatocyte  chromosome  aberration  test  were  conducted.  RESULTSAmes  test  showed  no  two- fold  increase  in  the  spontaneous  reversion  colonies  compared  with  the  negative  control  group  (P>0.05).  No  significant  difference  was  found  in  chromosome  aberration  and  micronucleus  rate  between  control  and  experimental  groups  (P>0.05). CONCLUSION24-dichlorophenoxyacetic  acid  showed  no  mutagenicity  under  these  test  conditions.

Key words:  2, 4-dichlorophenoxyacetic acid, Ames test, chromosome  , aberration, micronucleus;mutagenesis