Abstract:

 OBJECTIVE: To study the subchronic dermal toxicity of sodium lactate in rats，and analyze the target organ damage and its reversibility. METHODS：Sodium lactate was given to rats by transdermal administration at dose of 2 000，1 000 and 500 mg/kg for 90 days. Some rats from each group were sacrificed at 7th，13th week and 4 weeks after recovery，blood count and biochemistry were tested，ophthalmic and urinalysis tests were performed，wet weight of individual organs and the coefficient values were determined，and anatomic pathology were observed. RESULTS：With all treatment doses，K+，Cl- decreased and Na+，Ca2+ increased，protein precipitation was found in the bladder lumen. High dose group showed urinary protein and bilirubin concentration increased，specific gravity reduced. The above had dose-response relationship. Na+ values in high dose group remained elevated in the recovery stage. CONCLUSION： Sodium lactate showed significant toxic effects in rats as determined by mild disturbance of electrolyte and abnormal urinary protein.

Key words: subchronic dermal toxicity, sodium lactate, rats, electrolyte, urinary protein