重金属对秀丽线虫毒性排序的Meta回归分析

doi:10.3969/j.issn.1004-616x.2013.03.010

Abstract

Abstract:

OBJECTIVE: Based on the published literature of heavy metal toxicity on Caenorhabditis elegans，and after controlling the effects of other factors，we analyzed and compared the toxicity of heavy metals on Caenorhabditis elegans. METHODS：We used Scan It software to extract data from 20 related literature which contained figures expressing different indices of toxicity of various heavy metals on Caenorhabditis elegans，we then built a Meta regression model using toxicity indices as the dependent variables，and different metals，concentration，exposure time，etc. as independent variables. RESULTS：The order of heavy metal on the mortality of Caenorhabditis elegans was：Mercury (Hg)＞Copper (Cu)＞Lead (Pb)＞Chromium (Cr)＞Aluminum (Al)＞Cadmiun (Cd)＞Cobalt (Co)＞Nickel (Ni)＞Zinc (Zn)；affecting body size was：Pb＞Silver (Ag)＞Hg＞Co＞Al＞ Cr＞Zn＞Calcium (Ca)＞Ni；the effect on general time was：Ni＞Al＞Co＞Ag＞Cr＞ Zn＞Cu＞Pb； with head thrashes was：Hg＞Pb＞Ni＞Ag＞Cu＞Zn＞Cr＞ Co＞Cd＞Al. CONCLUSION：Meta regression model could be used to integrate information on the toxicity of different heavy metals，and to sort them in order. However，more experimental data on sorting of toxicity is necessary to validate the toxicity of some metals.

Key words: meta regression, toxicity sorting of heavy metal, Caenorhabditis elegans

WANG Meng，YU Xiao-jin，MIN Jie，LIU Ran，TANG Meng. Meta regression analysis of heavy metal toxicity on Caenorhabditis elegans[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2013.03.010.

References

[1] 张燕芬，王大勇. 利用模式动物秀丽线虫建立环境毒物毒性的评估研究体系[J]. 生态毒理学报，2008，3 (4)：313-322.

[2] 陈耀龙，于洁，张文娟，等. 循证医学术语介绍VII[J]. 中国循证医学杂志，2009，9 (12)：1272-1276.

[3] Chu KW，Chow KL. Synergistic toxicity of multiple heavy metals is revealed by a biological assay using a nematode and its transgenic derivative[J]. Aquat Toxicol，2002，61 (1/2)：53-64.

[4] Wang Y，Xie W，Wang DY. Transferable properties of multi-biological toxicity caused by cobalt exposure in Caenorhabditis elegans[J]. Environ Toxicol Chem， 2007，26 (11)：2405-2412.

[5] Xing X，Rui Q，Wang D. Lethality toxicities induced by metal exposure during development in nematode Caenorhabditis elegans[J].Bull Environ Contam Toxicol，2009，83 (4)：530-536.

[6] Wang DY，Yang P. Silver exposure causes transferable defects of phenotypes and behaviors in nematode Caenorhabditis elegans[J]. Environ Bioindicators，2007，2 (2)：1-10.

[7] 王大勇，胡亚欧，许雪梅. 铬暴露导致的秀丽线虫多重毒性的世代间比较[J]. 生态毒理学报，2007，2 (3)：297-303.

[8] Wang DY，Yang P. Multi-biological defects caused by lead exposure exhibit transferable properties from exposed parents to their progeny in Caenorhabditis elegans[J]. J Environ Sci， 2007，19 (110)：1367-1372.

[9] 汪洋，王大勇. 铜中毒引起的秀丽线虫世代间可传递的缺陷[J]. 安全与环境学报，2007，7 (2)：10-14.

[10] Wang DY，Wang Y. Nickel sulfate induces numerous defects in Caenorhabditis elegans that can also be transferred to progeny[J]. Environ Pollution，2008，151 (3)：585-592.

[11] Wang DY，Xing XJ. Assessment of locomotion behavioral defects induced by acute toxicity from heavy metal exposure in nematode Caenorhabditis elegans[J]. J Environ Sci，2008，20 (9)：1132-1137.

[12] Wang DY，Shen LL，Wang Y. The phenotypic and behavioral defects can be transferred from zinc-exposed nematodes to their progeny[J]. Environ Toxicol Pharmacol，2007，24 (3)：223-230.

[13] Wang DY，Xing XJ. Pretreatment with mild metal exposure suppresses the neurotoxicity on locomotion behavior induced by the subsequent severe metal exposure in Caenorhabditis elegans[J]. Environ Toxicol Pharmacol，2009，28 (30)：459-464.

[14] 王大勇，杨燚超，汪洋. 秀丽线虫中铝暴露导致的多重毒害在世代间具有可转移特性[J]. 中华预防医学杂志，2009，43 (1)：45-51.

[15] Xing XJ，Du M，Zhang YF，et al. Adverse effects of metal exposure on chemotaxis towards water-soluble attractants regulated mainly by ASE sensory neuron in nematode Caenorhabditis elegans[J]. J Environ Sci，2009，21 (12)： 1684– 1694.

[16] Wang HH，Robert L. Wick，Xing BS. Toxicity of nanoparticulate and bulk ZnO，Al2O3 and TiO2 to the nematode Caenorhabditis elegans[J]. Environ Pollution，2009， 157 (4)：1171-1177.

[17] Wang DY，Liu PD，Yang YC，et al. Formation of a combined Ca/Cd toxicity on lifespan of nematode Caenorhabditis elegans[J]. Ecotoxicol Environ Saf，2010，73 (6)：1221-1230.

[18] Zhang YF，Ye BP，Wang DY. Effects of metal exposure on associative learning behavior in nematode Caenorhabditis elegans[J]. Arch Environ Contam Toxicol，2010，59 (1)：129-136.

[19] Ye BP，Rui Q，Wu QL，et al. Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes[J]. PLoS One，2010，5 (11)：1-12.

[20] Wu QL，Yang P，Wang DY. Mercury exposure can cause transferable defects of phenotypes and behaviors in nematode Caenorhabditis elegans progeny[J]. J Southeast Univ：Med Sci Edi，2010，29 (1)：1-9.

[21] Yang YC，Xing XJ，Wang DY. The close association of pharyngeal pumping with mean lifespan can be observed in metal exposed nematode Caenorhabditis elegans[J]. J Southeast Univ：Med Sci Edi，2010，29 (1)：10-16.

[22] Wu QL，He KW，Liu PD，et al. Association of oxidative stress with the formation of reproductive toxicity from mercury exposure on hermaphrodite nematode Caenorhabditis elegans[J]. Environ Toxicol Pharmacol，2011，32 (2)：175-184.

[23] Lau J，Ioannidis JP，Schmid CH. Summing up evidence：one answer is not always enough[J]. Lancet，1998，351 (9096)： 123-127.

Meta regression analysis of heavy metal toxicity on Caenorhabditis elegans

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