Notch1在腺样囊性癌组织中的表达及其对预后的影响

doi:10.3969/j.issn.1004-616x.2013.02.014

Abstract

Abstract:

OBJECTIVE: To investigate the expression of Notch1 in adenoid cystic carcinoma，and analyze the relationship between its expression with clinicopathologic characteristics and its impact on prognosis. METHODS： Using immunohistochemistry to assess Notch1 expression in 38 patients with adenoid cystic carcinoma (ACC) and normal small oral glands，follow-up information and to analyze the relationship between Notch1 expression and clinicopathological data and its impact on prognosis. RESULTS：The positive rates of Notch1 expression in ACC and normal small oral gland were 81.6% and 30%，respectively (P<0.05)，and Notch1 expression was positively correlated with pathological type，T stage and infringement of adjacent tissue (r=0.550，P=0.002；r=0.741， P=0.001；r=0.523， P=0.005). Pathological type，lymph node metastasis，expression of Notch1，T stage， infringement of adjacent tissue were related to survival，as determined via single survival analysis. Notch1 expression and tumor stage were independent prognostic factors for ACC patients. CONCLUSION：Adenoid cystic carcinoma growes slowly with easy relapse，the expression of Notch1 may play an important role in development of ACC，and has potential value in prognostic evaluation.

Key words: Notch1, adenoid cystic carcinoma, prognosis, immunohistochemistry

ZHAO Hua1，ZHANG Kai1，*，JIANG Lei2，WANG Guo-wen2. The expression and prognostic impact of Notch1 in adenoid cystic carcinoma andthe study of prognosis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2013.02.014.

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The expression and prognostic impact of Notch1 in adenoid cystic carcinoma andthe study of prognosis

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