青岛地区人乳头状瘤病毒感染亚型与肺鳞状细胞癌的相关性

doi:10.3969/j.issn.1004-616x.2013.02.007

Abstract

Abstract:

OBJECTIVE: To find out the prevalence and subtype distribution of human papillomavirus (HPV) among lung squamous cell carcinomas (SCC). METHODS：We collected and examined 196 paraffin sections of lung SCC in Qingdao patients for the presence of HPV with polymerase chain reaction (PCR) and dot hybridization. RESULTS：We found that 58.16% of (114/196) all samples were positive for HPV. The four main types were HPV6 (48/196，24.49%)，HPV16 (61/196，31.12%)，HPV18 (4/196，2.04%) and HPV58 (1/196，0.51%). HPV6 mainly existed in the low-grade malignant squamous carcinoma，while HPV16 was mainly found in highly malignant squamous carcinoma. There were correlations between smoking (92.98%)，male gender (70.18%) and HPV positive rate in lung squamous carcinoma. CONCLUSION：There was an obvious relationship between the HPV subtype and the lung SCC. The study provided a theoretical basis for the preventive treatment of HPV vaccine on lung SCC.

Key words: human papillomavirus genotype, polymerase chain reaction, lung cancer, squamous cell carcinomas

GAO Zhi-di，SHAO Wei，LI Li，MA Xiao-ye， SUN Yu-ping. The correlation between HPV infection subtype and lung squamous cell carcinoma in Qingdao region[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2013.02.007.

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The correlation between HPV infection subtype and lung squamous cell carcinoma in Qingdao region

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