Abstract:

OBJECTIVE:  To investigate the reproductive and developmental effects of triazophos in rats over multiple generations. METHODS：P(parental generation)and F1 (filia 1 generation) parent rats were fed triazophos at doses of 0，0.210，1.456 and 7.167 mg/(kg·d) for 8 weeks before breading. The weights of main organs，breeding indexes and pathological changes were observed in P and F1 parents. The growth indexes of the offsprings were measured such as weight，body and tail lengths，and F1/F2 weanlings were sacrificed with reproductive organs weighed. RESULTS：The reproductive index was normal. The 1.456 and 7.167 mg/(kg·d) groups of P and F1，body weights of pregnant rats were decreased (P＜0.05). The 1.456 and 7.167 mg/(kg·d) groups of F1 and F2，the lengths of rat tail at d4，d7，d14 and d21 were shorter than those of control group (P＜0.05)，and the litter size and litter weights were lower than those of control group (P＜0.05). CONCLUSION：Under this experiment condition，triazophos had reproductive toxicity in rats. The harmful effects in the offsprings included delayed tail growth，reduced litter size and litter weight . No observed adverse effect level(NOAEL) over two generations was 0.210 mg/(kg·d). Low observed adverse effect level(LOAEL) over two generations was 1.456 mg/(kg·d).

Key words: triazophos, reproductive toxicity, reproductive index, productive index, birth index