c_myc与PCNA在哈萨克族食管癌组织中的表达及其临床相关性研究

doi:10.3969/j.issn.1004-616x.2010.06.005

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2010, Vol. 22 ›› Issue (6): 433-435.doi: 10.3969/j.issn.1004-616x.2010.06.005

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Expressions and clinical correlative study of c_myc and PCNA in Hazak's esophageal cancer

LI Hui1, WANG Hong-jiang2, CHEN Yan3, PANG Zuo-liang2,ZHANG Li-ping3, LI Hui-wu1,

1. Department of Science Research Center, Pre_clinical Medical College；2. Department of Biochemistry, Pre_clinical Medical College；3. Department of Thoracic Surgery, Affiliated Cancer Hospital, Xinjiang Medical University, Urumqi 830011, China

Received:2010-06-28 Revised:2010-10-14 Online:2010-11-30 Published:2010-11-30
Contact: LI Hui-wu

Abstract

Abstract: OBJECTIVE: To study the expressions and correlation of c_myc and PCNA in Hazak's esophageal cancer tissues, and to investigate the relationship between their expressions and the clinical pathological features. METHODS: We investigated mRNA expressions of c_myc and PCNA in 48 Hazak's esophageal cancer specimens by RT_PCR. The relationship between clinical pathologic features and expressions of c_myc and PCNA mRNA level were analyzed. RESULTS: The positive rates of c_myc and PCNA mRNA in cancer tissues were higher than normal tissues,were 56.3％and 47.9％(P<0.05), respectively. There were significant differences in the expressions of c_myc in the clinical early stage specimens(P<0.05). CONCLUSION: The expressions of c_myc and PCNA may be related to the carcinogenesis and progression of Hazak's esophageal cancer. C_myc gene may play an important role in the early stage of Hazak's esophageal cancer.

Key words: esophageal cancer, c_myc, PCNA

LI Hui, WANG Hong-jiang, CHEN Yan, PANG Zuo-liang, ZHANG Li-ping, LI Hui-wu, . Expressions and clinical correlative study of c_myc and PCNA in Hazak's esophageal cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2010, 22(6): 433-435.

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Expressions and clinical correlative study of c_myc and PCNA in Hazak's esophageal cancer

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