Carcinogenesis, Teratogenesis & Mutagenesis ›› 2009, Vol. 21 ›› Issue (1): 46-049.doi: 10.3969/j.issn.1004-616x.2009.01.011

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The Expressions of Cx43 Protein and Cx43 mRNA in Skin Scar and Scar Carcinoma

GUO Rui-zhen1，WANG Juan1，CHEN Shi-jiu2，TANG Wen-tai3，WU Xiao-mei2   

  1. 1. Pathology Department of Zhuhai Campus of Zunyi Medical College, Zhuhai 519041, Guangdong; 2. No.5 Affiliated Hospital of Zunyi Medical College,Zhuhai 519100, Guangdong;3. Pathology Department of No.1 Affiliated Hospital of Zunyi Medical College, Zunyi 563003,Guizhou,China
  • Received:2008-09-04 Revised:2008-10-09 Online:2009-01-30 Published:2009-01-30

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Abstract: BACKGROUND AND AIM: To study the relationship between malignant transformation of skin scar and connexin 43(Cx43) protein and Cx43 mRNA. MATERIALS AND METHODS: We compared skin scar and skin scar carcinoma with normal skin tissues. The expressions of Cx43 protein was evaluated by immunohistochemical S-P method, and the expression of Cx43 mRNA was assessed by in situ hybridization. RESULTS: The expressions of Cx43 and Cx43 mRNA in normal epidermis, skin scar epithelium and skin scar carcinoma were strongly positive, positive and weakly positive, respectively. The expressions of Cx43 protein and Cx43 mRNA in skin scar epithelium and scar carcinoma were statistically different to that in normal skin epidermis. The expression levels of Cx43 protein and Cx43 mRNA showed positive correlation in skin carcinoma tissues. CONCLUSION: The low expressions of Cx43 proteins and Cx43 mRNA may play important roles in the development or progression of skin scar carcinoma.

Key words: Cx43, skin scar, malignant transformation