白头翁水提物的抗诱变和抗氧化作用的初步研究

doi:10.3969/j.issn.1004-616x.2008.06.017

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (6): 481-482.doi: 10.3969/j.issn.1004-616x.2008.06.017

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Preliminary Study on Antimutag-enesis and Antioxidation of Aqueous Extract of Pulsatilla Chinensis Regel

LIU Zhong-ping1, PANG Hui-min2,ZHAO Yun-xiao3,ZHU Yu-zhuo2,

1.Deparment of Histology and Embryology,Jilin Medical College，Jilin 132013,Jilin; 2.Department of Medical Genetics,Jilin University, Changchun 130021,Jilin; 3.Emergency Centre,Changchun 130062,Jilin, China

Received:2008-03-03 Revised:2008-05-06 Online:2008-11-30 Published:2008-11-30

Abstract

Abstract: BACKGROUND AND AIM:To study the antimutagenesis and antioxidation properties of aqueous extract of Pulsatilla Chinensis Regel. MATERIALS AND METHODS: Tested the micronucleus rate of bone marrow PCE cell in mice, serum superoxide dismutase(SOD)activity and total anti-oxidative abilities(T-AOC)in mice serum by CP as mutagen and Vit C as control of antioxidant. RESULTS: The aqueous extract of Pulsatilla Chinensis Regel reduced the micronucleus rate of bone marrow PCE cell in mice，and increased SOD activity and T-AOC in mice serum. CONCLUSION: The aqueous extract of Pulsatilla Chinensis Regel showed antimutagenesis and antioxidation activities.The mechanism may lie in eliminating free radicals，interrupting and terminating oxidizing reaction of free radicals,and enhancing the overall anti-oxidative abilitiy.

Key words: pulsatilla chinensis regel, cyclophosphamide, antimutagenesis, antioxidation

LIU Zhong-ping, PANG Hui-min, ZHAO Yun-xiao, ZHU Yu-zhuo, . Preliminary Study on Antimutag-enesis and Antioxidation of Aqueous Extract of Pulsatilla Chinensis Regel[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(6): 481-482.

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Preliminary Study on Antimutag-enesis and Antioxidation of Aqueous Extract of Pulsatilla Chinensis Regel

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