Abstract: BACKGROUND AND AIM: To investigate the anti-mutation property of the Periplaneta Americana and Aspongopus Chinensis Dallas mixture. MATERIALS AND METHODS: Broad beans from Qiliqiao village and Xiaoguanyi village were divided into 4 groups, cyclophosphamide group, negative control group, Periplaneta Americana and Aspongopus Chinensis Dallas mixture group, Periplaneta Americana and Aspongopus Chinensis Dallas mixture＋cyclophosphamide group.The purpose was to assess the anti-mutation property of Periplaneta Americana and Aspongopus Chinensis Dallas mixture by means of micronucleus test of Vicia Faba L.root tip cells. RESULTS: Compared with the cyclophosphamide group, the rates of micronucleus in the Periplaneta Americana and Aspongopus Chinensis Dallas mixture＋cyclophosphamide group were lower. The inhibitory rates of Periplaneta Americana and Aspongopus Chinensis Dallas mixture＋cyclophosphamide group were 60.5％(Qiliqiao) and 52.5％(Xiaoguanyi). CONCLUSION: Periplaneta Americana and Aspongopus Chinensis Dallas mixture could effectively inhibit the mutation induced by cyclophosphamide.

Key words: Periplaneta americana, Aspongopus Chinensis Dallas, Vicia faba L, micronucleus, cyclophosphamide, anti-mutation