膀胱癌患者外周血淋巴细胞染色体畸变研究

doi:10.3969/j.issn.1004-616x.2008.02.021

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (2): 160-162.doi: 10.3969/j.issn.1004-616x.2008.02.021

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Study on Chromosome Aberration of Lymphocytes in Peripheral Blood of Patients With Bladder Carcinoma

GUAN Jing1,MENG Lin2,GAO Li1

1.Department of Biology ,Jining Medical College,Jining 272013, Shandong,China; 2.Department of Urology,Affiliated Hospital of Jining Medical College,Jining 272013,China

Received:2006-07-21 Revised:2007-06-11 Online:2008-03-30 Published:2008-03-30

Abstract

Abstract: BACKGROUND AND AIM: To investigate the relationship between chromosome numerical aberration of lymphocytes in peripheral blood and clinical stage ,pathological grading and prognosis in patients with bladder carcinoma. MATERIALS AND METHODS: Cytogenetic studies were taken on 30 bladder carcinoma by examining their chromosome numerical aberration of lymphocytes in peripheral blood. RESULTS: The frequencies of hypodiploid, hyperdiploid and polyloid were significantly increased.The general abnormality rate was significantly higher than the normal control group (P<0.05 ).As the clinical staging and pathological grading became more advanced,the diploid rate was reduced. CONCLUSION: With higher malignant degree of bladder carcinoma, the range of chromosome numerical aberration increased. This indicated that the appearance of polyloidy was closely correlated with the malignant level of the carcinoma and unfavourable prognosis.

Key words: bladder neoplasms, carcinoma, lymphocytes, chromosome aberration

GUAN Jing, MENG Lin, GAO Li. Study on Chromosome Aberration of Lymphocytes in Peripheral Blood of Patients With Bladder Carcinoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(2): 160-162.

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Study on Chromosome Aberration of Lymphocytes in Peripheral Blood of Patients With Bladder Carcinoma

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