Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (1): 33-35.doi: 10.3969/j.issn.1004-616x.2004.01.010

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Experimental Study of Anti-tumor Effect of Baofeixiaoliu Capsule on Lung Adenocarcinoma

LI Yu;YANG Su-xia;ZHOU Shu-zhen;et al   

  1. Beijing Center for Disease Prevention and Control,Beijing 100013 , China
  • Received:2003-04-14 Revised:2003-06-29 Online:2004-01-30 Published:2004-01-30
  • Contact: LI Yu

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Abstract: BACKGROUND ＆ AIM: To study the anti-tumor effect of “Baofeixiaoliu" capsule. MATERIAL AND METHODS: Using tumor inhibition model in vitro and in vivo to study the anti-tumor effect . RESULTS: It was showed that “Baoganxiaoliu" capsule between the doses of 80 and 320 mg/kg, had significantly inhibitory effect on nude mice bearing lung adenocarcinoma. The inhibition rate was above 48 ％. The inhibition rate of the dose of 160 mg/kg was near that of 5-Fu.It was also showed in vitro that after exposure to “Baofeixiaoliu" capsule , the growth of lung adenocarcinoma cells was inhibited, mitotic index was reduced and the structure of the cells was destroyed.The experimental result in vitro was in correspondence with that of animal model. CONCLUSION: “Baofeixiaoliu" capsule had tumor inhibition effect both in vitro and in vivo.

Key words: Baofeixiaoliu capsule, lung adenocarcinoma, nude mice