蒲公英对环磷酰胺致小鼠骨髓细胞突变作用的抑制研究

doi:10.3969/j.issn.1004-616x.2003.03.011

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (3): 164-167.doi: 10.3969/j.issn.1004-616x.2003.03.011

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THE EFFECT OF TARAXACUM MONGO TO INHIBIT THE MUTATION IN THE BONE MARROW LYMPHOCYTE OF MICE INDUCED BY CYCLOPHOSPHAMIDE

ZHU Wei-yun, PANG Zhu-lin, LIANG Min-yi, et al

Department of Medical Genetics and Cell Biology, Guangzhou Medical College, Guangzhou 510182,China

Received:2002-11-07 Revised:2003-02-06 Online:2003-07-30 Published:2003-07-30
Contact: ZHU Wei-yun

Abstract

Abstract: Purpose:To study the effects of Taraxacum mongo(TM) on anti-mutation and cell proliferation. Methods: Mitotic Index(MI), chromosome aberration and micronucleus test in bone marrow lymphocytes of mice were determined. Results: ①The MI of bone marrow lymphocytes in mice were in hibited by CP(P < 0.01),but MI were significantly increased compared with control group after TM oral feeding on mice (P < 0.01). ②The inhibition rates of chromosome aberration were 39.62 ％, 58.49 ％ and 54.72 ％ ,respectively by TM in different concentrations of low, medium and high, furthermore the frequencies of micronucleus(MN) were inhibited by CP(P > 0.05). Conclusion: No mutagenicity was observed on TM .but TM possesses the ability of anti - mutation,and promotes cell proliferation.

Key words: Taraxacum mongo, cyclophosphamide, mitotic index, chromosome aberration, micronucleus

ZHU Wei-yun, PANG Zhu-lin, LIANG Min-yi, et al. THE EFFECT OF TARAXACUM MONGO TO INHIBIT THE MUTATION IN THE BONE MARROW LYMPHOCYTE OF MICE INDUCED BY CYCLOPHOSPHAMIDE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2003, 15(3): 164-167.

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THE EFFECT OF TARAXACUM MONGO TO INHIBIT THE MUTATION IN THE BONE MARROW LYMPHOCYTE OF MICE INDUCED BY CYCLOPHOSPHAMIDE

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