Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (2): 79-80.doi: 10.3969/j.issn.1004-616x.2003.02.005

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EFFECT OF CYCLOPHOSPHAMIDE ON THE ABILITY OF LYMPHOCYTES PROLIFERATION IN NORMAL MICE

LUO Hong-qing1, MENG Qing-yong2   

  1. 1. Department of Clinical Laboratory, Blood Center of Shaoguan City, Shaoguan 512026, China; 2. Analysis Center of Guangdong Medical College, Zhanjiang 524023, China
  • Received:2002-10-01 Revised:2002-12-26 Online:2003-04-30 Published:2003-04-30
  • Contact: LUO Hong-qing1

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Abstract: Purpose: To observe the effect of cyclophosphamide(CP) on the ability of splenic lymphocyte transformation and spontaneous proliferation of thymocytes in normal mice. Methods: 3H-TdR incorporation technique was used. Results: The proliferation of splenic lymphocyte was significantly enhanced by CP in the concentration of 10-8 and 10-7 mol / L, but was markedly reduced by CP in the oncentration of more than 10-3 mol / L. CP in the concentration of 10-3 mol / L could 16.increase spontaneous proliferation of thymocyts, while CP in the concentration of more than 10-2 mol / L inhibited it. Conclusion: Large dose of CP inhibited immune function and low dose of CP enhanced it in normal mice.

Key words: cyclophosphamide, dose-effect, lymphocyte, proliferation