Abstract: Purpose : To observed the inhibition effect of osthol on human lung adenocarcinoma and squamacarcinoma. Methods : Set up models of human lung adenocarcinoma and squamacarcinoma on the bodies of BALB/ C ,one kind of nude mice , then osthol was given to the mice in the dose of 1. 5μg/ (g·d) . Antitumor effect of osthol were valued by weighing the tumor and determing DR 2 70 , the mark of lung cancer in BALB/ C serum.Results : The inhibitory rates were 69. 5 % on lung squamacarcinoma , and 50 % on lung adenocarcinoma , respectively also obviously decreased the level of serum DR270. Conclusion : Osthol can inhibite the growing of lung adenocarcinoma and lung squamacarcinoma , especially the squamacarcinoma.

Key words: osthol, lung cancer, nude mice