Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (4): 202-204.doi: 10.3969/j.issn.1004-616x.2000.04.003

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EFFECT OF HBsAg DNA VACCINE ON MOUSE ORGANS

FANG Ling ，YAO Yu一Cheng2，JING Hong—Biao,XIE Qing—dong，ZHAO Shu—min2．YU Hong — yu2;HU Yi— ping;Wang Zhong-hua   

  1. 1．Department ofBiology，Gu~ngo：[Medical University，Nanning 530021，China；2．Department of Cell Biology，Second Military Medical University，Shanghai 200433，China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2000-10-30 Published:2000-10-30

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Abstract: To study the pathological change Of organs of mice immunitied byⅫ Ag DNA vaccine．Methods： HBsAg vaccine was i~ected into muscles of mice Anti—HBsAg antibody w analyzed by ELISA．After 12 weeks，the immunitied mi ce were killed and those organs were analyzed by pathological methods． Results：Anti 一Ⅻ Ag antibody in mice was positive after one wek．Spleens of mice were 4 folds larger than contro1． Kindeys and 1Nets were severe iniured．Conclusion：sAg vacine can induce mice to create antibody，lasting 12 weeks and more．But，pathology ch~rlge of organs indicated that the production of vaccine or related react_ may give rise tO the damage of the organs of mice ．This result make~to study the．safety of H&Ag vaccine further

Key words: Hepa titis B virus, surface an tigen, DNA vaccine, pathology change

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