Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (6): 345-348.doi: 10.3969/j.issn.1004-616x.1998.06.004

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HOMOZYGOUS DEFICIENCY OF HUMAN GLUTATHIONE STRANSFERASE T1 GENE IN NORMAL POPULATION IN SHANGHAI

Lin Guofang ,Tan J ingwei ,Shen J ianhua   

  1. S ino2German L aboratory of Toxicology in S hanghai ( DCL T) , Shanghai Institute of Entomology , Academia Sinica , Shanghai 　200025
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-11-30 Published:1998-11-30

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Abstract: Human glutathione S2t ransferase ( GSTs) is considered as an important group of phase reaction enzymes involved not only in the detoxification metabolism ,in some cases , also in the bioactivation process of various types of environmental hazard chemicals. Among the glutathione S2t ransferases known so far , GSTT1 displays genetic polymorphism due to gene deletion. GSTT1 was genotyped in 226 healthy adults in Shanghai (permanent resident s) by an internal control allele2specific PCR amplification of blood nucleated cell DNA. The homozygous deletion of gene ( GSTT10/ 0 genotype) was identified in 50. 3 %(114/ 226) of the individuals tested. The deficiency frequency in normal population in Shanghai is higher than in normal Caucasian population (11 - 17 %) and among Af rican Americans (24 %) significantly.

Key words: glutathione S-transferase T1, Normal population, Gene deficiency