Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (3): 189-192.doi: 10.3969/j.issn.1004-616x.2008.03.006

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The Expression of Survivin and Its Relationship with Cellular Proliferation and Apoptosis in Differentiated Thyroid Carcinoma

QIAN E-na1,XU Zheng-shun2,WANG Yang-kun3,MENG Nian-long3,YUAN Xu-tao3,QIAO Liang3, YANG Hai-xia1, ZHANG Luo1   

  1. 1.Department of Pathology,Affiliated First Hospital of Henan Science and Technology University,Luoyang 471003;2.Affiliated Medical College of Henan Science and Technology University,Luoyang 471003;3.The 150 Central Hospital of China People Liberation Army,Luoyang 471001, Henan,China
  • Received:2007-08-06 Revised:2007-10-25 Online:2008-05-30 Published:2008-05-30

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Abstract: BACKGROUND AND AIM: To investigate the expression of Survivin protein and its relationship with cellular proliferation and apoptosis in differentiated thyroid carcinoma(DTC),and to identify the mechanism and pathway of Survivin in thyroid tumorigenesis. MATERIALS AND METHODS: The terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) technique was used to measure the apoptosis index(AI). Expression of Survivin protein and proliferating cell nuclear antigen(PCNA) in 10 cases of nodular goiters (NG),10 thyroid adenomas (TA),30 papillary thyroid carcinoma(PTC) and 12 follicular thyroid carcinoma (FTC) were determined by immunohistochemistry staining. RESULTS: The positive staining rate of Survivin in thyroid carcinoma was higher than that in control group (P<0.01). The expression of Survivin in thyroid carcinoma was related to lymph node metastasis and clinical stage(P<0.05). In DTC group AI was negatively related with the PI in patients with positive survivin expression and in patients with negative Survivin expression(r=－0.72，r=－0.80，P<0.01),respectively.In DTC，the PI in patients with positive Survivin expression was higher than that in patients with negative Survivin expression. However,the AI in patients with positive Survivin expression was lower than that in patients with negative Survivin expression(P<0.01). CONCLUSION: Survivin demonstrated a closed relationship with cellular proliferation and apoptosis in differentiated thyroid carcinoma.It may play an important role in the development of thyroid carcinoma .

Key words: thyroid carcinoma, Survivin protein, apoptosis, proliferation